Pharmacokinetics Simulations
The primary objective of the package, Pharmacokinetics Simulations, is to teach the basic principles of pharmacokinetics through computer simulations.
Simulation of the plasma drug concentration-time profile is a valuable tool to understand the basic pharmacokinetic principles and to appreciate the interplay of various pharmacokinetic parameters.
In this package, a user can select a pharmacokinetic model, adjust one or more pharmacokinetic parameters and evaluate how changes in the parameter(s) affect the resulting plasma drug concentration-time profile. Results can be plotted either on a linear scale or on a semilog scale; the user can easily switch between linear and semilog scales.
Information about the pharmacokinetic model and equation(s) used for the calculations in a simulation can be seen at any point when working through a simulation.
Product Code: COP004
Price: £300 p.a. (per institution)
Pharmacokinetics Simulations covers the following:
- IV bolus drug administration
- Oral drug administration
- Constant rate IV infusions
- Intermittent IV infusions
- Single and multiple administration
- Loading doses
- Linear and nonlinear drug elimination
- One and two compartment pharmacokinetic models
The main pharmacokinetic parameters covered are:
- Elimination rate constant
- Volume of distribution
- Half-life
- Total Body Clearance
- Area Under The Concentration-Time Curve
- Bioavailability
- First Order Absorption Rate Constant
- Dose
CONTENTS OF THE PACKAGE
Pharmacokinetics Simulations consists of the following sections and activities:
Introductory Section: Introduction And Examples Of Using The Simulations
Introduction
- Introduction
Examples Of Using The Simulations
- Single Oral Dose
- Multiple Oral Doses
- Constant Rate IV Infusion
- Nonlinear Elimination
- Two Compartment Models
Main Section: The Simulations
Section 1: Introduction To Pharmacokinetic Parameters
- Elimination Rate Constant (k)
- Volume Of Distribution (Vd)
- Half-Life (t1/2)
- Total Body Clearance (TBC)
- Area Under The Concentration-Time Curve (AUC)
- Bioavailability (F)
- First Order Absorption Rate Constant (ka)
- Dose (D)
Section 2: IV Bolus Administration
One Compartment Models
- Single IV Bolus Dose
- Multiple IV Bolus Doses
- Loading Dose And Multiple Doses
Two Compartment Models
- Single IV Bolus Dose
- Multiple IV Bolus Doses
- Loading Dose And Multiple Doses
Section 3: Oral Administration
One Compartment Models
- Single Oral Dose
- Multiple Oral Doses
- Loading Dose And Multiple Doses
Two Compartment Models
- Single Oral Dose
- Multiple Oral Doses
- Loading Dose And Multiple Doses
Section 4: Multiple Administration
One Compartment Models
- Multiple IV Bolus Doses
- Multiple Oral Doses
Two Compartment Models
- Multiple IV Bolus Doses
- Multiple Oral Doses
MM Elimination/Nonlinear Elimination
- Multiple Oral Doses
Section 5: Constant Rate IV Infusion
One Compartment Models
- Constant Rate IV Infusion
- Loading Dose And Constant Rate IV Infusion
Two Compartment Models
- Constant Rate IV Infusion
- Loading Dose And Constant Rate IV Infusion
Section 6: Intermittent IV Infusion
One Compartment Models
- Single Short IV Infusion
- Multiple Short IV Infusions
- Loading Dose And Multiple Short IV Infusions
Two Compartment Models
- Single Short IV Infusion
- Multiple Short IV Infusions
- Loading Dose And Multiple Short IV Infusions
Section 7: Multiple Compartments
Two Compartment Models
- Single IV Bolus Dose
- Multiple IV Bolus Doses
- Single Oral Dose
- Multiple Oral Doses
- Constant Rate IV Infusion
- Loading Dose And Constant Rate IV Infusion
Central And Peripheral Profiles
- Single IV Bolus Dose
- Multiple IV Bolus Doses
Section 8: Nonlinear/MM Elimination
- Single IV Bolus Dose
- Single Oral Dose
- Multiple Oral Doses
- Single IV Bolus Dose: Nonlinear Elimination In Presence OF Competitive Inhibitor
The package allows users to simulate the effects of adjusting one or more pharmacokinetic parameters for a range of pharmacokinetic models.
Pre-requisites: Users should have a basic knowledge of pharmacokinetic parameters.
Audience: Undergraduate pharmacy and pharmacology students; people working in the medical profession for whom a knowledge of basic pharmacokinetic principles and pharmacokinetic parameter interplay would be useful.
Time to complete: The package contains over 40 simulations; time to complete the package is dependent on how many simulations a user works through and how long the user spends in a single simulation.
There are currently no reviews available for this package.
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Main CoAcS website
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- pharmacy education
- healthcare applications to hospitals and pharma
- bespoke software
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Please contact us directly if you wish to arrange a subscription.