Pharmacokinetics Simulations covers the following:

• IV bolus drug administration
• Oral drug administration
• Constant rate IV infusions
• Intermittent IV infusions
• Single and multiple administration
• Loading doses
• Linear and nonlinear drug elimination
• One and two compartment pharmacokinetic models

The main pharmacokinetic parameters covered are:

• Elimination rate constant
• Volume of distribution
• Half-life
• Total Body Clearance
• Area Under The Concentration-Time Curve
• Bioavailability
• First Order Absorption Rate Constant
• Dose

CONTENTS OF THE PACKAGE

Pharmacokinetics Simulations consists of the following sections and activities:

Introductory Section: Introduction And Examples Of Using The Simulations

Introduction

• Introduction

Examples Of Using The Simulations

• Single Oral Dose
• Multiple Oral Doses
• Constant Rate IV Infusion
• Nonlinear Elimination
• Two Compartment Models

Main Section: The Simulations

Section 1: Introduction To Pharmacokinetic Parameters

• Elimination Rate Constant (k)
• Volume Of Distribution (V_d)
• Half-Life (t_1/2)
• Total Body Clearance (TBC)
• Area Under The Concentration-Time Curve (AUC)
• Bioavailability (F)
• First Order Absorption Rate Constant (k_a)
• Dose (D)

 Section 2: IV Bolus Administration

One Compartment Models

• Single IV Bolus Dose
• Multiple IV Bolus Doses
• Loading Dose And Multiple Doses

Two Compartment Models

• Single IV Bolus Dose
• Multiple IV Bolus Doses
• Loading Dose And Multiple Doses

Section 3: Oral Administration

One Compartment Models

• Single Oral Dose
• Multiple Oral Doses
• Loading Dose And Multiple Doses

Two Compartment Models

• Single Oral Dose
• Multiple Oral Doses
• Loading Dose And Multiple Doses

Section 4: Multiple Administration

One Compartment Models

• Multiple IV Bolus Doses
• Multiple Oral Doses

Two Compartment Models

• Multiple IV Bolus Doses
• Multiple Oral Doses

MM Elimination/Nonlinear Elimination

• Multiple Oral Doses

 Section 5: Constant Rate IV Infusion

One Compartment Models

• Constant Rate IV Infusion
• Loading Dose And Constant Rate IV Infusion

Two Compartment Models

• Constant Rate IV Infusion
• Loading Dose And Constant Rate IV Infusion

 Section 6: Intermittent IV Infusion

One Compartment Models

• Single Short IV Infusion
• Multiple Short IV Infusions
• Loading Dose And Multiple Short IV Infusions

Two Compartment Models

• Single Short IV Infusion
• Multiple Short IV Infusions
• Loading Dose And Multiple Short IV Infusions

 Section 7: Multiple Compartments

Two Compartment Models

• Single IV Bolus Dose
• Multiple IV Bolus Doses
• Single Oral Dose
• Multiple Oral Doses
• Constant Rate IV Infusion
• Loading Dose And Constant Rate IV Infusion

Central And Peripheral Profiles

• Single IV Bolus Dose
• Multiple IV Bolus Doses

Section 8: Nonlinear/MM Elimination

• Single IV Bolus Dose
• Single Oral Dose
• Multiple Oral Doses
• Single IV Bolus Dose: Nonlinear Elimination In Presence OF Competitive Inhibitor